Androgen receptor (AR )

Androgen receptor is primary receptor for testosterone and dihydrotestosterone. Its main function is development and maintenance of the male sexual phenotype. For details see Wikipedia and Proteopedia.


Estrogen receptor alpha (ER α)

Estrogen receptors are included in estrogen receptor-like subfamily with estrogen related and 3-ketosteroid receptors.There are two different forms of the estrogen receptor (α and β), each encoded by a separate gene.The ERα is found in endometrium, breast cancer cells, ovarian stroma cells, and the hypothalamus. For more see Wikipedia and Proteopedia.


Estrogen receptor beta (ER β)

Estrogen receptors are included in estrogen receptor-like subfamily with estrogen related and 3-ketosteroid receptors.There are two different forms of the estrogen receptor (α and β), each encoded by a separate gene.The ERβ is found in kidney, brain, bone, heart, lungs, intestinal mucosa, prostate, and endothelial cells. For more see Wikipedia and Proteopedia.


Glucocorticoid receptor (GR)

Glucocorticoid receptor is nuclear receptor belonging to 3-ketosteroid receptors. It regulates development, metabolism and immune response. For details see Wikipedia and Proteopedia.


Liver X receptor alpha (LXR α)

Liver X receptors are classified into subfamily thyroid hormone receptor-like and are important regulators of cholesterol, fatty acid and glucose homeostasis. There are two different isoforms of the liver x receptor (α and β). For more information see Wikipedia.


Liver X receptor beta (LXR β)

Liver X receptors are nuclear receptors classified into subfamily thyroid hormone receptor-like. There are two different isoforms of the liver x receptor (α and β) which have different expression in different tissues. For more information see Wikipedia.


Peroxisome proliferator-activated receptor alpha (PPAR α)

Peroxisome proliferator-activated receptors are group of three different forms (α, β and γ) classified into subfamily thyroid hormone receptor-like. Their major function is regulation of metabolism, development, cell differentiation and carcinogenesis. Peroxisome proliferator-activated receptor α role is regulating lipid metabolism in liver. For more details see Wikipedia.


Peroxisome proliferator-activated receptor beta (PPAR β)

Peroxisome proliferator-activated receptor β or also known as peroxisome proliferator-activated receptor δ was linked to be involved in the development of cancer, obesity, diabetes and atherosclerosis. For additional details see Wikipedia.


Peroxisome proliferator-activated receptor gamma (PPAR γ)

Peroxisome proliferator-activated receptor γ is the most studied receptor from the group. Similarly as peroxisome proliferator-activated receptor β, it was also implicated in the development of cancer, obesity, diabetes and atherosclerosis. Its major role is regulating metabolism of glucose and storage of fatty acids, therefore it is also a target for anti-diabetic drugs. For more see Wikipedia and Proteopedia.


Retinoid X receptor alpha (RXR α)

Retinoid X receptor α is one of the three existing forms of retinoid X receptors. Retinoid x receptors forms heterodimers with peroxisome proliferator-activated receptors, vitamin D receptor and others. With this heterodimerization retinoid x receptors regulates transcription of target genes of its partner. For more details see Wikipedia and Proteopedia.


Thyroid hormone receptor alpha (TR α)

Thyroid hormone receptors α and β are encoded by two genes. They regulate metabolism, heart rate and play critical roles in the development. For additional informations see Wikipedia.


Thyroid hormone receptor beta (TR β)

Thyroid hormone receptors β and α are not steroid hormone receptors and are activated by triiodothyronin. They regulate metabolism, heart rate and play critical roles in the development. For additional informations see Wikipedia.