Abbreviation: PPAR γ

Peroxisome proliferator-activated receptor γ is the most studied receptor from the group. Similarly as peroxisome proliferator-activated receptor β, it was also implicated in the development of cancer, obesity, diabetes and atherosclerosis. Its major role is regulating metabolism of glucose and storage of fatty acids, therefore it is also a target for anti-diabetic drugs. For more see Wikipedia and Proteopedia.

Performance

This is an overview of the performance of our protocols on different forms of peroxisome proliferator-activated receptor gamma

Active

Tresholds
Score Sensitivity Specificity PPV NPV
-10.30.2540.95710.298.5
-9.60.5060.8536.298.9
-8.90.7930.654.299.4

More negative score means greater possibility for binding.

Sensitivity represents fraction of true positives.

Specificity represents fraction of true negatives.

Files: 3ET3, conf_PPARgamma, ,